Comparison of Ondansetron and Metoclopramide in the Prevention of Post-Operative Nausea and Vomiting after Laparoscopic Cholecystectomy

Aim: To compare the efficacy of ondanstron and metoclopramide in the control of post-operative nausea and vomiting after laparoscopic cholecystectomy and to record side effects of either drug. Method: The study was carried out from 2007 to 2008 in the Department of Anaesthesia, Mayo Hospital, Lahore. Sixty female patients were divided into two groups of 30 each. Group O (ondansetron) was given injection ondansetron 2mg intravenously before induction. Group M (metoclopramide) was given inj metoclopramide 10mg slow intravenously before induction. The parameters like postoperative nausea and vomiting were measured at 12 hours post operatively. Results: In group O nausea was seen in 11(36.7%) patients and in group M it was seen in 17 (56.7%) patients. Severity of nausea was less in group O as compared to group M. Postoperative vomiting occurred in 12 (40%) patients in group O, 16 (53.33%) patients in group M. Severity of vomiting was also less in group O than M. Conclusion: Ondansetron was found to have better anti-emetic efficacy when compared with metoclopromide in control of PONV after laparoscopic cholecystectomy.